Anti-HIV activity
Result, opinion:
Betulenol (1) shows weak Anti-HIV  activity with EC50=23 micron and TI=1,9, i.e. betulenol is 16 times less active than betulenolic acid.
Based on the original natural compounds of betulenol (1) and betulinolic acid (2) with relatively low anti- HIV activity, by their chemical modification a number of highly active compounds have been found. The most promising semi-synthetic derivative of Lupane series include amides, dipeptides and esters of  betulenolic and betulinic acids.

Betulenol derivatives as promising Anti-HIV agents
A. Abyshev, R. Abyshev, V. Nguen, V. Morozova
St-Petersburg State Chemo-Pharmaceutical Academy
St-Petersburg center for prevention and combating AIDS and infectious deseasrs
Medical Academic Journal, 2013, vol. 13, №2

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