Anti-mutagenic properties
Model:
Cells accounting method with chromosome damage in C57Bl /6 mice.

Result, opinion:  
Dry birch barkextract (BED) was administered orally in doses of 50, 150, 450 and 1500 mg/ kg, mutagens - dioxidine (200 mg/kg) and cyclophosphamide (20 mg /kg) intraperitoneally.
The preceding analysis showed that the antimutagenic effect of naturally occurring compounds and their complexes practically does not exceed 50%. However, along with a positive antimutagenic effect, they often exhibit undesirable comutagenic action. BED is favorably unique in having effectiveness of antimutagenic action with no comutagenic effects. Its protective effect in a single preliminary administration in most cases is at least 60%.

Thus, the set of results obtained in the experiments on mammalia allows to conclude that BED is characterized by pronounced antimutagenic activity and has no undesirable mutagenic and comutagenic properties.




Source:
“Birch World” Ltd.
“Study of antimutagenic effect of birch bark extract”
Institute of Pharmacology after V. Zakusov RAMS, research under the direction of Professor A. Durneva.

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