For experts

Betulin has been long and widely used in medicine. The spectrum of proven positive properties of betulin allows doctors to count on both the preventive and active effects of the substance in therapy.

Based on the original natural compounds of betulenol (1) and betulinolic acid (2) with relatively low anti- HIV activity, by their chemical modification a number of highly active compounds have been found. The most promising semi-synthetic derivative of Lupane series include amides, dipeptides and esters of  betulenolic and betulinic acids.
The preceding analysis showed that the antimutagenic effect of naturally occurring compounds and their complexes practically does not exceed 50%. However, along with a positive antimutagenic effect, they often exhibit undesirable comutagenic action. BED is favorably unique in having effectiveness of antimutagenic action with no comutagenic effects. Its protective effect in a single preliminary administration in most cases is at least 60%.
It can be concluded that the sum of triterpenoids from birch bark is an effective bacteriostatic agent against microorganisms such as Staphylococcus aureus, Bacillus antracoides, Eschericha coli and Salmonella typhimurium, and also retards the growth of dermatophyte fungi Candida albicans and Aspergillus niger. High activity against Aspergillus niger in prospective opens  possibilities for the use of birch triterpenoids in veterinary with regard to frequent contamination of farm animals with these microorganisms.
Glucose tolerance and insulin resistance significantly improve when using betulin.
The chloroform extract of Alnus oregona has antitumor activity against Walker 256 (5WA16) tumor system. Two components of the extract that are responsible for this activity have been identified - lupeol and betulin.
BED provides immune modeling effect on phagocytosis in intact animals as well as in mice on influenza pneumonia model. BED more actively enhances individual cell activity: the value of the FI and the FF in infected animals is almost 2 times higher than those in intact mice. Therefore , BED activates the main function of macrophages - phagocytosis.
Reseach show membrane-acting of dry birch barkextract in relation to the microsomal membrane. Dry birch bark extract in vitro and in vivo is a substance that competes for binding sites with the 3-metoxibenzantron (MBA) probe improves its permeability, increasing the polarity of deep membrane layers.
According to the biochemical in vitro testing it can be assumed that the dry birch barkextract obtained by the original technology of “Birch World” Ltd. may have a sufficiently wide range of pharmacological effects and show antioxidant and adaptogenic properties.